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Meanings and definitions for OTB

Off the boat, a slang phrase for newly arrived immigrants
Off-track betting, sanctioned gambling on horse racing outside a race track
Overberg Test Range, or Overberg Toetsbaan, a missile test range in South Africa
Over-the-board chess, played between opponents seated at the same chessboard (as opposed to correspondence or online chess)
Overseas Trust Bank, a defunct bank of Hong Kong
On the Boards, a Seattle, Washington arts organization
Off the ball, a player's movement when not in possession of the ball in football
One True Brace, a software coding convention for formatting loops, functions, if statements, and blocks
Orfeo toolbox, an open source library for remote sensing image processing
Out of the Blue (band), an American jazz ensemble founded by Blue Note Records in the 1980s
OTB Group, a holding company for several fashion brands
The Old Timer's Bulletin an amateur radio history journal
OTA Bitmap, a specification designed by Nokia for black and white images for mobile phones (*.otb files)
Off Track Betting